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Konstantin PopovPlease join me in welcoming Dr. Konstantin Popov as a new faculty member, Research Associate Professor in the Division of Chemical Biology and Medicinal Chemistry, and Director of Computational Biophysics, here in the Center.

Konstantin comes to us from a Research Assistant Professor position in the Department of Biochemistry and Biophysics at UNC. His research expertise is at the interface of computational and structure-guided chemical probe and drug discovery, which is a vital part of the mission of the CICBDD.

Konstantin received his PhD in polymer physics and chemistry from Moscow State University, Russia in 2009. While getting his PhD, he worked part time as a research associate at the Schlumberger Moscow Research Center. He subsequently received a year of postdoctoral training in nano drug delivery research at Northwestern University under the mentorship of Professor Monica Olvera de la Cruz. Following four additional years of postdoctoral research applying computational methods to cell motility at the University of Maryland at College Park, under the supervision of Professor Garegin Papoian, Dr. Popov was appointed as Research Assistant Professor at the Department of Biochemistry and Biophysics at UNC in 2014. At UNC he has established numerous collaborations including ones with Professors Alexander Tropsha and Andrew Lee within the Eshelman School of Pharmacy, as well as numerous other faculty in the Center and across campus. With these latter collaborations, he has been heavily involved in several recent grant applications and awards toward new anti-viral therapeutics. He will also be an important contributor to several ongoing programs toward Alzheimer’s and cancer chemical probes and therapeutics.

We are looking forward to having Konstantin be a central researcher, collaborator, and leader here in the Center.  Feel free to stop by and introduce yourself.

KENNETH H. PEARCE, PhD
Research Professor, Division of Chemical Biology and Medicinal Chemistry
Director, Center for Integrative Chemical Biology and Drug Discovery
Director, Lead Discovery and Characterization

 

 

Lead Generation Through Scientific Collaboration

 

A leading academic center focused on translating UNC biomedical science into the discovery of small molecule medicines and chemical research tools.

 

The Center’s mission is to bring dedicated medicinal chemistry expertise to bear on biological targets of therapeutic relevance under investigation by UNC faculty. Synthetic chemists, assay development and compound profiling scientists work in the Center and create dedicated, multidisciplinary project teams with other groups on campus to progress targets through the drug discovery and early development process. The first targeted therapeutic from the Center designed to reactivate the innate immune response in cancer and block survival signaling pathways in many solid and hematologic malignancies is advancing through clinical trials. In addition to collaborative drug discovery projects, the Center has a basic science focus in the area of chromatin regulation. The Center’s chromatin science is centered on methyl-lysine as a posttranslational modification and the protein-protein interactions that it facilitates. The first chemical probes for methyl-lysine reader proteins were discovered in the CICBDD and are being used to validate novel interventions in cancer and other diseases.