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Ken Pearce, PhDKen Pearce, PhD, Director CICBDD


Lab Members



The Lead Discovery and Characterization group (LD&C) assists UNC faculty and external collaborators with the development and validation of biochemical and cell-based assays for primary and secondary screening.  Multiple platforms and readouts are possible (see equipment below). Screens of up to 200K compounds are possible using our multiple libraries, both internal and collaborative.  A realistic timeline from initiation of assay development to completion of screening is approximately one  year.  This time will vary based on the state of target validation at the start of a project.  We prioritize focused screens and knowledge-based approaches to maximize utilization of resources and changes of success.

LD&C handles all compound management for the Center and is equipped to develop screening assays using industry standard best practices and technologies. The equipment within LD&C is organized around an “islands of automation” concept where each device is capable of walk away operation sufficient to process 30-50 plates. This strategy has been proven to be maximally effective in environments where flexibility is required and assays formats may vary significantly over time. All equipment is maintained at or above the manufacturers recommended maintenance intervals for testing and calibration.