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Xcovery Acquires Majority Controlling Stake in Meryx Pharmaceuticals December 07, 2021 08:00 AM Eastern Standard Time PALM BEACH GARDENS, Fla.–(BUSINESS WIRE)–Xcovery Holdings, Inc., an oncology focused bio-pharmaceutical company, is proud to announce the acquisition of a majority and controlling stake … Read more

May 19, 2021 Dr. Samantha Pattenden, Associate Professor within the Division of Chemical Biology and Medicinal Chemistry, and Director of Applied Epigenetic Screening Technologies in the Center for Integrative Chemical Biology and Drug Discovery, and Dr. Ian Davis, Professor, Pediatrics … Read more

May 14, 2021 Dr. Xiaodong Wang, a Research Professor within the Center for Integrative Chemical Biology and Drug Discovery, and its Director of Medicinal Chemistry was awarded over $1.5 million from NIH along with her collaborator, Douglas Graham, PhD of … Read more

Tops $2 million, supports small molecule research to identify new approaches to modulating drug target Brittany Jennings March 26, 2021   Each day, Stephen Frye, Ph.D., works to identify pharmacologic approaches to intervene in novel drug targets within stephen_fryethe human … Read more

Dr. Samantha Pattenden, Associate Professor, joined the CICBDD in 2010 as a Postdoctoral Research Associate and in 2015 was promoted to Assistant Professor, Director of Applied Epigenetic Screening Technologies. In 2017 she co-founded Triangle Biotechnology, Inc. with Dr. Paul Dayton … Read more

Thursday November 5, 2020 “Technology Development for Inhibitor Discovery of Chromatin Associated Proteins Linked to Lysine Methylation” Seminar based upon the doctoral dissertation of Justin M. Rectenwald under the direction of Dr. Ken Pearce and Dr. Stephen Frye.   Abstract … Read more

Xiaodong’s most impactful project focuses on discovery of potent and selective TAM tyrosine kinase inhibitors. This project has resulted in a clinical candidate that is progressing through Phase 1 studies at UNC and Emory University. Dr. Wang led the medicinal … Read more

Cathy Anderson, a graduate student in the UNC Department of Biochemistry and Biophysics, has been awarded the NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00). Anderson was selected as the UNC nominee last fall and has now been awarded this … Read more

The goal of the Rapidly Emerging Antiviral Drug Discovery Initiative (READDI) is to develop antiviral drugs for epidemic and pandemic viruses. In the current environment, READDI is focused exclusively on identifying and developing antiviral drugs to treat and/or prevent COVID-19 … Read more

“It’s great to see the collaborative chromatin-focused science in the CICBDD recognized for its translational potential. Nate and Lindsey have created innovative programs that can hopefully lead to impact in patients with this initial support from the EII.” Stephen V. … Read more

Justin Rectenwald, graduate student and lab member of Dr. Stephen Frye and Dr. Ken Pearce   June 11, 2019 Justin Rectenwald has been awarded the 2019 Diane Harris Leadership Award for exemplary public service as a doctoral student in the … Read more

  Veronica Correa October 1, 2019   A group of researchers from the University of North Carolina at Chapel Hill are part of a new research proposal to create chemical and biological tools to explore novel molecular targets related to … Read more

Chemical Biology and Medicinal Chemistry Brittany Jennings October 30, 2019 Lindsey Ingerman James, Ph.D. Lindsey Ingerman James, Ph.D., with the UNC Eshelman School of Pharmacy is interested in epigenetic abnormalities that lead to cancer. For example, misregulation of the NSD2 … Read more

Veronica Correa November 27, 2019 Nathaniel Hathaway, Ph.D., a researcher at the UNC Eshelman School of Pharmacy’s Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery and the Lineberger Comprehensive Cancer Center, was published … Read more

Chemical Biology and Medicinal Chemistry Brittany Jennings December 18, 2019 Alliance Between UNC-Chapel Hill and Deerfield intends to advance select Carolina innovations toward a possible new treatment against multiple myeloma Lindsey Ingerman James, Ph.D. Pinnacle Hill, the research and development … Read more

In 2016 a number of scientists, including our own Jeff Aube and Sarah Scarry embarked on a study of small molecules.  What they found surprised many. The enzymes PptT and PptH have been found to perform opposing reactions in Mtb … Read more

It is a great honor and accomplishment for Aleksandra to receive this competitive ACS postdoctoral fellowship. She was selected among the top applicants based on her past research accomplishments, her research plans for her postdoctoral studies, and her promise as … Read more

  Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1 Junghyun L. Suh† , Brian Watts‡, Jacob I. Stuckey†§, Jacqueline L. Norris-Drouin†, Stephanie H. Cholensky†, Bradley M Dickson†∥ , Yi An†, Sebastian Mathea⊥▼, … Read more

Recently Laura Oleniacz, UNC Lineberger Comprehensive Cancer Center, interviewed Stephen Frye to feature highlights of his accomplishments on their Facebook page.  Open this link for a  peek.  Consider posting it on your own FB pages, or even donating to the … Read more

Three members of CICBDD (Center for Integrative Chemical Biology and Drug Discovery) provide commentary to Nature Chemical Biology, October 2017 edition.  Read the article here.

Stephen Frye has announced new Director roles in the CICBDD for Samantha Pattenden and Lindsey James based on their ongoing contributions to the mission of the Center.  These titles will make visible their role in fostering collaborations with other UNC … Read more

The Graduate School at UNC-CH hosted the Summer Undergraduate Pipeline Research Symposium. It brought students and their mentors together to showcase the work that the 139 undergraduates from across the country participated in over the last few weeks.  Representing 14 … Read more

Edward Leete Award Purpose To recognize outstanding contributions to teaching and research in Organic Chemistry Nature The award will be presented no more than biennially during the fall national meeting of the American Chemical Society. The Award consists of a … Read more

Congratulations, Dmitri! The Eshelman Innovation Institute (EII) recently granted two awards to Dmitri Kireev.  The EII Tier 1 award allows him to  study “Taming entropic pseudo-forces for chemical biology and drug discovery.  The second award is an EII Tier 2 … Read more

Katherine Hayes Joins CICBDD for Two Weeks Katherine Hayes, from the LA area, came to UNC to learn about Chemistry and Drug Discovery.  On the recommendation of her teacher, she approached us with hopes of seeing a lab in operation, … Read more

Congratulations are in order for Samantha Pattenden, Paul Dayton (Biomedical Engineering) and Ian Davis (Genetics, Pediatric Hematology/Oncology) for their award, National Cancer Institute Innovative Molecular Analysis Technologies Program R33. Formalin-fixed paraffin embedded (FFPE) patient biopsy samples are an important source … Read more

Kelsey Lamb has been selected to receive a 2017-2018 ACS MEDI Pre-doctoral Fellowship.  The ACS Division of Medicinal Chemistry Predoctoral Fellowship is a prestigious award that has been given annually since 1991.  Many of the recipients of this award have … Read more

Robert McGinty, M.D., Ph.D., an assistant professor in the Division of Chemical Biology and Medicinal Chemistry at the UNC Eshelman School of Pharmacy, has been selected as a 2017 Searle Scholar. He is the first Searle Scholar named at the … Read more

Along with Mauro Calabrese (Pharmacology), Samantha Pattenden was granted a Tier 1 award from the Eshelman Institute for Innovation.  The award allows them to develop small molecule probes to inhibit the regulatory capacity of long noncoding RNAs. Molecules called long … Read more

Read the entire article by Lisa M. Jarvis, Senior Correspondent, C&EN.        

Samantha Pattenden has led a team of UNC scientists to a successful Institutional Development Grant application from the North Carolina Biotechnology Center for the project Advanced Acoustic Sonication for High Throughput Nucleic Acid Fragmentation, Biospecimen Processing, and Drug Discovery.   The … Read more

Oliver Bell, PhD IMBA – Institute of Molecular Biotechnology   Oliver Bell will visit UNC on April 10 and 11.  At 4 PM on Tuesday, April 11, he will present a seminar in Bioinformatics 1131 titled,  “The silent Polycomb revolution – … Read more

Congratulations to Tigran Abramyan who has been approved for a domestic travel award from the Office of Postdoctoral Affairs (OPA).  Tigran will attend the 253rd ACS National Meeting & Exposition, to present research conducted in collaboration with the Lineberger Comprehensive … Read more

   Read: His tagged cryocapture – Langmuir 2016 The Center for Integrative Chemical Biology and Drug Discovery Presents: David H. Thompson, PhD Professor – Organic Chemistry Purdue University   “Development of New Tools for Accelerated Protein Structure Determination and Reaction … Read more

Thanks to the North Carolina Biotechnology Center Institutional Development Grant (NCBC IDG) program, the CICBDD and the Hooker Imaging Core were awarded $200,000 to support the purchase of a high content cell imaging system.  Matching funds for the instrument were … Read more

October 6, 2016 By David Etchison The University of North Carolina at Chapel Hill will pursue treatments for specific cancer targets as a specialized member of the National Cancer Institute’s renewed Experimental Therapeutics, or NExT, program. Because of its unique … Read more

R01 Stephen Frye, PhD and Lindsey James, PhD will collaborate with PI Matt Redinbo, PhD on his R01 grant from NCI entitled Microbiome-Targeted Probes to Eliminate Chemotherapy-Induced GI Toxicity.  The overarching hypothesis is that microbial enzymes expressed by the GI … Read more

Rob was born in Muscatine, Iowa, and adds “but spent all of my school age years in Portland, Oregon. Since then I have been an academic nomad with undergraduate studies at Iowa State University followed by graduate work in the … Read more

Kimberly Diane Barnash, Kelsey N Lamb, Jacob I Stuckey, Jacqueline L. Norris-Drouin, Stephanie H Cholensky, Dmitri B. Kireev, Stephen V. Frye, and Lindsey I. James ACS Chem. Biol., Just Accepted Manuscript DOI: 10.1021/acschembio.6b00415 Publication Date (Web): June 29, 2016 Copyright … Read more

Thanks to the North Carolina Biotechnology Center Institutional Development Grant (NCBC IDG) program, the CICBDD and the Hooker Imaging Core were awarded $200,000 to support the purchase of a high content cell imaging system.  Matching funds for the instrument were … Read more

March 21, 2016 By Laura Oleniacz, UNC Lineberger Comprehensive Cancer Center Read the entire article here .

Story by Susan Hudson, University Gazette Video by Carly Swain, Office of Communications and Public Affairs Published March 30, 2016   Read the article in its entirety here. http://www.unc.edu/spotlight/pharmacy-school-celebrates-top-ranking/

Dr. Sarah Scarry was appointed to the position of Research Assistant Professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy.  Dr. Scarry will be expanding her medicinal chemistry expertise into the arena … Read more

On March 16, 2016, Dave Etchison writes, “The UNC Eshelman School of Pharmacy is number one in the latest rankings by U.S. News & World Report of the nation’s Doctor of Pharmacy programs in the 2017 edition of “America’s Best … Read more

February 16, 2016 an IND was opened for clinical trials of MRX2843 (UNC2371) in patients with solid tumors. On March 1, 2016 a patent was issued for UNC2371 (MRX2843 as licensed to Meryx Inc., http://meryxpharma.com/home).  The inventors Xiaodong Wang, Jing … Read more

Using New Screening Tool, UNC Researchers Identify Potential Treatments for Ewing Sarcoma March 1, 2016 By Laura Oleniacz, UNC Lineberger Comprehensive Cancer Center Stephen Frye, Ph.D., directs the School’s drug discovery center, which played a key role in the recent … Read more

  Jacob Stuckey (PhD Candidate 2016) and colleagues report in Nature Chemical Biology the first cellularly active chemical probe (UNC3866) for any member of the chromodomain family of proteins that recognize, or “read” methylated lysine.  Specifically, the probe inhibits the … Read more

On December 1, 2015, Dr. Samantha Pattenden received word that she is the recipient of a $7500 IBM Junior Faculty Development Award. Congratulations!

We are pleased to announce that our very own Nate Hathaway has been named a 2016 recipient of the AACP New Investigator Award. Nate’s award centers around the “Development of Novel Inhibitors of Mammalian Heterochromatin Gene Repression.”  View all the … Read more

Lindsey James, Steve Headey (Monash University, Australia), Ken Pearce and Stephen Frye have been awarded a grant by the PharmAlliance Research Working Group and Deans to assist in funding preliminary data for the project “Discovery of Inhibitors for the Methyl-Lysine … Read more